January 18, 2010 — Individuals with treatment-resistant depression tend to have the G/G genotype associated with higher levels of 5-HT 1A autoreceptors, and turning off some of those autoreceptors ...

Autistic adults show reduced availability of a key glutamate receptor, mGlu5, across widespread brain regions.

Opioid receptors are a subset of G protein–coupled receptors (GPCRs). These membrane proteins transmit signals into the cell ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists is to control that process, making cells respond how they want to what ...

Yale School of Medicine (YSM) scientists have discovered a molecular difference in the brains of autistic people compared to ...

More than 1,000 bitter-tasting compounds are recognized by a repertoire of 26 membrane proteins called the type-2 taste receptors (TAS2Rs), also known as the bitter taste receptors 1, 2. Our ...

G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to transmit signals inside the cell.

"G-protein coupled receptors, normally, can be activated by specific small molecules that bind in a pocket in the receptor," explained Nicholas Kalogriopoulos, a postdoctoral fellow in the Ting lab ...