We have fractionated crude porcine heparin to obtain highly active as well as relatively inactive species of molecular weight ≈ 7000 with specific anticoagulant activities of 360 and 12 units/mg, ...

Overview: Heparin is a blood thinner that is used to prevent or treat blood clots. It may be injected under the skin or into a blood vessel. The most common side effects are irritation at the ...

This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

If biomolecules were people, heparin would be a celebrity. Best known as a powerful blood thinner with a global market of more than $7 billion, heparin is used during and after surgery and is ...

The global supply chain for bovine and porcine heparin and regulatory considerations are examined. Heparin regulates hemostasis at various points of the coagulation cascade mainly through its ...