Cytochrome P450 (P450) and chloroperoxidase (CPO) are thiolate-ligated haem proteins that catalyse the activation of carbon hydrogen bonds. The principal intermediate in these reactions is a ferryl ...

Cytochrome P450 mono-oxygenases (P450s) are the principal enzymes involved in the oxidative metabolism of drugs and other xenobiotics. In this protocol, we describe a fluorescence-based, ...

Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various ...

Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles ...

Neurodegenerative disorders are pressing global health challenges that stem from progressive neuronal dysfunction and loss. While the central roles of ...

Outcome After Pathologic Complete Eradication of Cytologically Proven Breast Cancer Axillary Node Metastases Following Primary Chemotherapy We determined cytochrome P450 (CYP)2D6 (*4 and *6) and ...

Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC). This is an ASCO ...

WEST LAFAYETTE, Ind. —Bed bugs tuck themselves away into dark, unseen spaces and multiply rapidly, making them difficult to control. That job has gotten even harder in recent years as the pests have ...